SIF 4th Cohort Fellows - Luce Perie, CY Cergy Paris University

Curriculum Vitae

 

• Education

ORCID

Research Project:

Aging is a significant risk factor in ovarian cancers, with ovarian cancer being particularly lethal, affecting over 50% of women aged 65 and older. Among these patients, some develop an inflammatory fluid known as ascites, containing matrix and inflammatory molecules. This can facilitate ovarian cancer cells dissemination and promote the entry of neighboring cells into a senescent state. The synergistic interaction between fibroblasts and ovarian cancer cells suggests the invasive nature of cancer cells. The secretome of senescent fibroblasts, particularly fibronectin, may further amplify this invasive trait. As the precise role of the senescent environment in ovarian cancer cell dissemination remains elusive, we propose to unravel how senescent fibroblasts influence the dissemination of ovarian cancer cells. First, we will explore the impact of inflammatory conditions on the fibroblast secretome, examining whether these conditions can modify the senescent state of cells and searching for specific markers involved. Thus, we'll investigate how stress-induced senescent fibroblasts influence ovarian cancer behavior by analyzing the cancer cell response to the senescent fibroblast secretome. This will involve measuring cell dissemination capacity through assessments of proliferation, adhesion, and migration. Lastly, scavenging the expression of molecules secreted by senescent fibroblasts will be explored to determine its potential to alleviate ovarian tumor progression. This ambitious project combines clinical, basic science and multiplex analysis to achieve its objectives of understanding the molecular dialogue between senescent cells and ovarian cancer cells in an inflammatory context which could pave the way for the development of targeted therapies.